Tossup

Proteins that reverse this process bind Sin3 scaffolds to facilitate their upregulation by retinoblastoma protein. This process can be inhibited when PCAF or the p300/CBP complex perform this process on themselves. Inhibitors like SAHA and tricho·statin A stabilize this process (10[1])in conjunction with drivers of it like the SAGA complex and MYST proteins. (10[1])This process is reversed by enzymes that (10[1])use an NAD+ cofactor in place of zinc, called sirtuins (10[1])(“SIR-too-ins”). Proteins identify sites of this (10[1])process (10[1])via the binding of a four-alpha-helix cluster (10[1])called (-5[1])a bromodomain. (10[3]-5[1])On (-5[1])lysines, this process (10[1])is carried out and reversed by HATs and HDACs, (10[1])respectively. (10[1])For 10 points, name this modification (10[1])that causes (-5[1])chromatin to open up to transcription when (10[1])performed on histones, (-5[1])and describes the addition of (-5[1])a COCH3 group. ■END■ (10[4]0[1])

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