glycosylation - 2025 ACF Nationals

Tossup

An uncommon form of this reaction can occur at normally unreactive W-X-X-W motifs. The progression of this reaction is usually depicted by the SNFG and Oxford notations as trees whose nodes consist of basic colored shapes. Cycles where this reaction is repeatedly performed and reversed (-5[1])allow calnexin to act as a quality control checkpoint (10[1])for misfolded proteins. (-5[1])A form of this reaction functionalizes (10[1])dolichol (“DOLL-ick-ol”) phosphate, (10[1])causing the newly formed molecule to flip (10[1])into the lumen. Localization of this reaction (10[1])depends on whether it uses asparagine (10[1]-5[1])or one of either serine or threonine (10[2]-5[1])as a reactant. The (10[1])O-linked and N-linked (10[2])forms (10[2])of this (10[2])post-translational (10[1])modification (10[1])are localized to the Golgi apparatus and endoplasmic reticulum, respectively. For 10 points, name this biochemical reaction in which a sugar is attached to a protein. (10[1])■END■ (10[4]0[3])

ANSWER: glycosylation [accept N-linked glycosylation or O-linked glycosylation; accept C-linked glycosylation; prompt on any answer that describes adding sugars or adding carbohydrates; reject “glycation”]

= Average correct buzz position

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Buzzes

Player	Team	Opponent	Position	Value
Tiffany Zhou	Florida	WUSTL B	44	-5
Bryan Ugaz	Arizona State	British Columbia	53	10
Alex Akridge	Indiana	Chicago A	56	-5
David Bass	Johns Hopkins	Texas	62	10
Marcus Forbes-Green	Toronto C	Cornell A	64	10
Tony Chen	Toronto A	Columbia A	71	10
Sharath Narayan	Northwestern	Rutgers	78	10
Rohan Shelke	UC Berkeley A	Stanford	84	10
Vinu Harihar	UC Berkeley B	Waterloo B	84	-5
Raymond Chen	Toronto B	Georgia Tech	91	10
Nathan Sheffield	MIT	Minnesota	91	-5
Shiva Tegulla	UCF	Virginia	91	10
Neal Joshi	WUSTL A	North Carolina A	95	10
Alan Xie	Yale	LSE	98	10
Teigue Kelly	Penn State	Georgia State	98	10
Adam Fine	Chicago A	Indiana	99	10
Andrew Wang	Illinois A	Waterloo A	99	10
Yashwanth Bajji	Michigan	Illinois B	101	10
Ryan Rosenberg	NYU	Ottawa	101	10
Ezra Santos	Chicago B	Virginia Tech	102	10
Shourjo Ganguli	Ohio State	Columbia B	103	10
Cade Reinberger	RIT	Maryland	129	10
Conor Thompson	Iowa State	Harvard	130	10
Puna Ekka	Minnesota	MIT	130	0
Henry Bon	Winona State	North Carolina B	130	10
Caleb Ott	Waterloo B	UC Berkeley B	130	10
Gavin Markoff	Vanderbilt	Cornell B	130	0
Julian Bushlow	Cornell B	Vanderbilt	130	0
John John Groger	WUSTL B	Florida	130	10

Summary

Tournament	Exact Match?	TUH	Conv. %	Power %	Neg %	Average Buzz
2025 ACF Nationals	Yes	24	92%	0%	17%	97.23