Tossup

These cells have gained interest as immunotherapy agents because they ubiquitously express programmable receptors named K·I·Rs. These cells, whose production in the uterus increases dramatically during pregnancy, are inactivated by trophoblastic expression of HLA-E. These cells express CD16 to bind IgG antibodies in a classical example (10[1])of (10[1])ADCC. (10[1])These cells’ expression (10[1])of CD56 and (10[1])lack of CD3 or TCRs allows them to be distinguished from T cells. The “missing self” hypothesis (10[2])aims to explain why these cells target cells that don’t display (10[1])MHC class I (“one”) markers. (-5[2])These cells release granules containing (10[1]-5[1])perforin (10[2])that allow (-5[1])subsequent entry of granzymes into the target cell. (10[1])For 10 points, name these innate immune cells that recognize and destroy non-self (-5[1])cells, (-5[2])like those infected by viruses and cancer cells. ■END■ (10[4]0[10])

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