Tossup
A method to produce 4-substituted examples of this functional group uses TBAF to activate calcium carbide and nitrone derivatives, and is named for Kinugasa. John C. Sheehan created three syntheses for this functional group, including the reaction intermediate 6-APA for the “benzyl” or “G” class of a molecule. A class of molecules named for this functional group is derived from the fungus Acremonium. The Ambler system classifies enzymes that cleave this functional group. They’re not azides, but molecules with this functional group are created by performing a 2+2 cycloaddition between a ketene (“KEE-teen”) and an imine (“IM-een”) in the Staudinger synthesis. Carbapenems (“CAR-buh-PEN-ems”) and cephalo·sporins contain a central example of this functional group. For 10 points, name these cyclic amides whose “beta-” variety is found in a class of antibiotics that includes penicillin. ■END■
ANSWER: lactams [or beta-lactams or beta-lactamases; accept cyclic amides until read; prompt on amides until read; reject “lactones”]
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